Nudibaccatumone, a Trimer Comprising a Phenylpropanoid and Two Sesquiterpene Moieties from <i>Piper nudibaccatum</i>

A new complex natural product with a C₃₉ skeleton, named nudibaccatumone, and the known sesquiterpenes (+)-spathulenol, (−)-4β,10α-aromadendranediol, and <i>ent</i>-T-muurolol, as well as the phenylpropanoid hydroxychavicol, were isolated from the aerial parts of <i>Piper nudibaccatum</i>. The structure and absolute configuration of nudibaccatumone were elucidated using spectroscopic methods and ECD calculations. A 1,8-Michael addition reaction and an intermolecular, inverse electron demand Diels–Alder reaction are proposed as the key steps in the biosynthesis of nudibaccatumone

Indole Alkaloid Glycosides from the Aerial Parts of <i>Strobilanthes cusia</i>

Three indole alkaloid glycosides, strobilanthosides A–C (<b>1</b>–<b>3</b>), two known indole alkaloid glucosides (<b>4</b> and <b>5</b>), and five phenylethanoid glycosides (<b>8</b>–<b>10</b>) were isolated from the aerial parts of <i>Strobilanthes cusia</i>. The structures of the new compounds were elucidated by spectrometric analysis, and the absolute configurations of <b>1</b> and <b>2</b> were established by ECD spectrocsopy. <i>N</i>′-β-d-Glucopyranosylindirubin (<b>5</b>) showed weak antibacterial activity (MIC 62.5–125 μM) against <i>Staphylococcus aureus</i>